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Bisthianostat

Chemical Structure : Bisthianostat

CAS No.: 1408234-79-6

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Bisthianostat (CF367)

Catalog No.: PC-24619Not For Human Use, Lab Use Only.

Bisthianostat (CF367) is an orally bioavailable pan-inhibitor of human histone deacetylase (HDAC) with IC50 of 0.07, 0.26 and 0.79 uM for HDAC1, HDAC2 and HDAC6 respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Bisthianostat (CF367) is an orally bioavailable pan-inhibitor of human histone deacetylase (HDAC) with IC50 of 0.07, 0.26 and 0.79 uM for HDAC1, HDAC2 and HDAC6 respectively.
Bisthianostat (CF367) displays potent activity against nine HDACs except HDAC7 and HDAC9.
Bisthianostat (CF367) induces histone acetylation in MEF cells and apoptosis in T cells.
Bisthianostat (CF367) (10 mg/kg) alleviates clinical symptoms of EAE in several autoimmune animal models.

Physicochemical Properties

M.Wt 366.45
Formula C15H18N4O3S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
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Solubility

10 mM in DMSO
Chemical Name/SMILES

5-cyclopropyl-N-[5-(hydroxyamino)-5-oxopentyl]-2-(1,3-thiazol-2-yl)-1,3-thiazole-4-carboxamide

References

1. Fei Chen, et al. ACS Med Chem Lett. 2014 Apr 4;5(6):628-33.

2. Patent WO2022058405 A2.

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