Catalog No.: PC-25110Not For Human Use, Lab Use Only.
Martinostat is a potent, selective inhibitor for class I and class-IIb HDACs with IC50 of 0.3/2.0/0.6 nM for HDAC1/2/3 and 4.1 nM for HDAC6 respectively, >100-fold selectivity over other HDAC isoforms.
Martinostat is a potent, selective inhibitor for class I and class-IIb HDACs with IC50 of 0.3/2.0/0.6 nM for HDAC1/2/3 and 4.1 nM for HDAC6 respectively, >100-fold selectivity over other HDAC isoforms.
[(11)C]Martinostat could be suesfor quantitative imaging of HDACs in vivo in the central nervous system and major peripheral organs.
Martinostat demonstrated enhanced anticancer effects when combined with imatinib, both in vitro and in vivo, significantly reducing tumor growth in resistant CML xenograft models.
