Chemical Structure : DS-103
CAS No.:
DS-103
(DS103)
Catalog No.: PC-23992Not For Human Use, Lab Use Only.
DS-103 is a potent HDAC inhibitor with IC50 of 29/123/23/367 nM for HDAC1/2/3/6, weakly inhibits HDAC8 and no activity against class IIa member HDAC4.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
DS-103 is a potent HDAC inhibitor with IC50 of 29/123/23/367 nM for HDAC1/2/3/6, weakly inhibits HDAC8 and no activity against class IIa member HDAC4.
Inhibition of HDAC1 and HDAC3 is 4–5-fold higher than that of HDAC2 and 13-fold stronger than inhibition of HDAC6.
DS-103 displays 13-fold preference for HDAC1 and HDAC3 over HDAC6.
DS-103 demonstrates single-digit micromolar antiplasmodial activity (3D7 IC50 of 5.08 μM).
DS-103 displays a low single-digit micromolar inhibitor of cell proliferation in Cal27 (IC50: 1.47 μM) and Cal27CisR cells (IC50: 2.23 μM) aginst head-neck carcinoma cell line Cal27 and its cisplatin-resistant subline Cal27Cis.
DS-103 completely reversed cisplatin resistance in two different platinum-resistant solid cancer cell lines and demonstrated strong synergism with cisplatin.
Physicochemical Properties
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M.Wt
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487.60
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Formula
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C28H33N5O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-[2-(Benzylamino)-2-oxoethyl]-4-(dimethylamino)-N-[4-(2-ethylhydrazine-1-carbonyl)benzyl]benzamide
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References
1. Stopper D, et al. J Med Chem. 2025 Feb 13. doi: 10.1021/acs.jmedchem.4c02373.
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