| Cat. No. |
Product Name |
Information |
| PC-20992 |
Yanostat
class I HDAC inhibitor
|
Yanostat (KH16) is a novel potent HDAC inhibitor with low nanomolar in vitro activity against class I HDACs (HDAC1/2/3 IC50=13/34/6 nM). |
| PC-49250 |
TYA-018
HDAC6 inhibitor
|
TYA-018 (TYA018) is a potent, isoform-selective inhibitor of HDAC6 with IC50 of 10 nM, inhibits tubulin acetylation (Ac-Tubulin) with EC50 of 120 nM in cell-based assay in induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs). |
| PC-49104 |
MPT0B390
HDAC1/2 inhibitor
|
MPT0B390 (B390) is a selective HDAC1/2 inhibitor and an effective inducer of metalloproteinase 3 (TIMP3), significantly upregulates TIMP3 expression in colorectal cancer cells. |
| PC-49072 |
KH-259
HDAC6 inhibitor
|
KH-259 is a potent, isozyme-selective and CNS-penetrant HDAC6 inhibitor with IC50 of 260 nM, shows weak activity against HDAC1 and HDAC4 (IC50>6 uM). |
| PC-49004 |
Dacinostat
HDAC inhibitor
|
Dacinostat (NVP-LAQ824) is a potent histone deacetylase (HDAC) inhibitor with IC50 of 32 nM, transcriptionally activates the p21 promoter in reporter gene assays with AC50 of 0.3 uM. |
| PC-73192 |
Domatinostat
Class I HDAC inhibitor
|
Domatinostat (4SC-202) is a selective class I HDAC inhibitor with IC50 of 1.20/1.12/0.57 uM for HDAC1/2/3, repectively. |
| PC-72886 |
IRBM6
Class I HDAC inhibitor
|
IRBM6 (Class I HDAC-IN-6) is a potent, class I selective HDAC inhibitor with EC50 of 50 nM (HeLa cellular), HDAC1/2/3 IC50 of 1.7/2.8/1.1 nM. |
| PC-72785 |
T-518
HDAC6 inhibitor
|
T-518 (T518) is a potent, highly selective, brain penetrant, oral HDAC6 inhibitor with IC50 of 36 nM. |
| PC-72739 |
KT-531
HDAC6 inhibitor.
|
KT-531 (KT531) is a potent, selective HDAC6 inhibitor with IC50 of 8.5 nM, displays 39-fold selectivity. |
| PC-72672 |
BRD4884
HDAC2 inhibitor
|
BRD4884 is a potent, kinetically selective HDAC2 inhibitor with IC50 of 29/62 nM for HDAC1/2, >17-fold selectivity versus HDAC3. |
| PC-72097 |
SIS17
HDAC11 inhibitor
|
SIS17 is a selective, cell-active HDAC11 inhibitor with IC50 of 0.83 uM. |
| PC-72091 |
NR-160
HDAC6 inhibitor
|
NR-160 (NR160) is a novel potent, selective inhibitor of histone deacetylase 6 (HDAC6) with IC50 of 30 nM, shows SI (75-1847 )over all HDAC class I isoforms. |
