| Cat. No. |
Product Name |
Information |
| PC-38635 |
NVP-CLR457
class I PI3K inhibitor
|
NVP-CLR457 (CLR457) is a potent, orally bioavailable, non-CNS-penetrant pan-class I PI3K inhibitor with IC50 values of 89 nM, 56 nM, 39 nM and 230 nM for p110α, p110β, p110δ and p110γ isoforms, respectively. |
| PC-38383 |
Amdizalisib
PI3Kδ inhibitor
|
Amdizalisib (HMPL-689) is a highly selective and potent oral inhibitor of phosphoinositide 3-kinase-delta (PI3Kδ) with potential antineoplastic activity. |
| PC-73424 |
Izorlisib
PI3K inhibitor
|
Izorlisib (MEN1611, CH5132799) is a potent, selective, orally available class I PI3K inhibitor with IC50 of 14/120/400/36 nM against PI3Kα/β/δ/γ, respectively. |
| PC-73420 |
Gilmelisib
PI3K inhibitor
|
Gilmelisib is a potent PI3K inhibitor with IC50 of <1 nM for PI3K p110α, exhibits antineoplastic acitvity. |
| PC-73277 |
PQR514
PI3K inhibitor
|
PQR514 is a potent selective pan-PI3K inhibitor with binding Ki of 2.2 and 33 nM for p110α and mTOR, repectively. |
| PC-72781 |
GSK251
PI3Kδ inhibitor
|
GSK251 is a highly potent, selective, orally bioavailable inhibitor of PI3Kδ with pKi of 10.9, >1,000-fold selectivity over other PI3K isoforms. |
| PC-72075 |
FAPL-PI3Ki1
FAP-targeted PI3K inhibitor
|
FAPL-PI3Ki1 is a specific FAP-targeted PI3K inhibitor that selectively targets FAP-expressing human IPF lung fibroblasts and potently inhibits collagen synthesis. |
| PC-38318 |
CPL302-253
PI3Kδ inhibitor
|
CPL302-253 is a potent, selective inhibitor of PI3Kδ with IC50 of 12.2 nM and Kd of 0.83 nM, >350-fold selectivity over PI3K isoforms α, β, and γ (IC50>4,500 nM). |
| PC-35993 |
B591
PI3K inhibitor
|
B591 (B-591) is a potent, specific pan-PI3K inhibitor with IC50 of 1.3/0.36/1.1/1.58 uM for PI3Kα/β/γ/δ, respectively. |
| PC-35887 |
CL27c
PI3K inhibitor
|
CL27c is a cell-permeable, inhaled lipophilic ester prodrug of CL27e, which is a potent, selective pan-class I PI3K inhibitor, CL27c is inactive in PI3K enzymatic assay, once inside the cytoplasm, CL27c is metabolized by unspecific esterases into CL27e. |
| PC-35880 |
SAR260301
PI3Kβ inhibitor
|
SAR260301 (SAR-260301, SAR 260301) is a potent, selective, ATP-competitive PI3Kβ inhibitor with IC50 of 52 nM in TR-FRET assays, with littile to no actiivty against PI3Kα/γ/δ (IC50=1,869/>10,000/403 nM, respectively). |
| PC-35868 |
BEBT-908
PI3K/HDAC inhibitor
|
BEBT-908 (BEBT908, CUDC-908) is a novel potent, dual PI3K/HDAC inhibitor with nanomolar IC50 values of <0.1 uM (PI3Kα) and 0.1-1 uM (HDAC). |
