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AZD8154

Chemical Structure : AZD8154

CAS No.: 2215022-45-8

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AZD8154 (AZD-8154)

Catalog No.: PC-38686Not For Human Use, Lab Use Only.

AZD8154 is a highly potent, selective dual PI3Kγ/δ inhibitor with cell pIC50 of 9.1/8.4, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AZD8154 is a highly potent, selective dual PI3Kγ/δ inhibitor with cell pIC50 of 9.1/8.4, respectively.
    AZD8154 inhibits the release of IL-5 and IL-17, and eotaxin-3 (CCL26)-induced CD11b expression in peripheral blood mononuclear cells (PBMCs).
    AZD8154 inhibits eosinophil migration in response to an inhaled ovalbumin challenge of allergic asthma model.

    Physicochemical Properties

    M.Wt 551.680
    Formula C27H29N5O4S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-2-(1-Cyclopropylethyl)-5-(4-methyl-2-((6-(2-oxopyrrolidin-1- yl)pyridin-2-yl)amino)thiazol-5-yl)-7-(methylsulfonyl)isoindolin-1- one

    References

    1. Perry MWD, et al. J Med Chem. 2021 Jun 24;64(12):8053-8075.

    2. Sadiq MW, et al. Br J Clin Pharmacol. 2022 Jan;88(1):260-270.

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