You are here:Home-Chemical Inhibitors & Agonists-PI3K/Akt/mTOR Pathway-PI3K-PF-06862309
PF-06862309

Chemical Structure : PF-06862309

CAS No.: 2067281-52-9

PF-06862309 (PF-06843195 phosphate ester prodrug)

Catalog No.: PC-49022Not For Human Use, Lab Use Only.

PF-06862309 (PF-06843195 phosphate ester prodrug) is the in vivo-active, phosphate ester prodrug of PF-06843195, a potent selective PI3Kα inhibitor with Kd of <18 pM.

Packing Price Stock Quantity
25 mg Get quote
100 mg Get quote
200 mg Get quote
1 g Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PF-06862309 (PF-06843195 phosphate ester prodrug) is the in vivo-active, phosphate ester prodrug of PF-06843195, a potent selective PI3Kα inhibitor with Kd of <18 pM.
PF-06862309 demonstrated robust PK/PD correlation and tumor growth inhibition (TGI) in mouse xenograft models with MDAMB361 and MCF7 cell lines.
PF-06862309 is a clinical candidate for treating breast cancer patients characterized with ER+ , HER2-, and harboring PIK3CA mutations.

Physicochemical Properties

M.Wt 578.446
Formula C20H26F3N8O7P
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2,2-difluoroethyl (S)-3-((2'-amino-5-fluoro-2-morpholino-[4,5'-bipyrimidin]-6-yl)amino)-3-((phosphonooxy)methyl)pyrrolidine-1-carboxylate

References

1. Cheng H, et al. J Med Chem. 2021 Jan 14;64(1):644-661.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: