| Cat. No. |
Product Name |
Information |
| PC-63379 |
Inavolisib
PI3Kα inhibitor
|
GDC-0077 (Inavolisib, RG-6114) is a potent, highly isoform selective inhibitor of PI3Kα, with IC50 of 0.038 nM. |
| PC-63276 |
LX-2343
PI3K inhibitor
|
LX-2343 (LX2343) is an non-ATP competitive PI3K inhibitor that negatively regulates AKT/mTOR signaling, thus promoting autophagy and increasing Aβ clearance, also inhibits BACE1 enzymatic activity with IC50 of 11.43 uM. |
| PC-43426 |
GDC-0980
PI3K/mTOR inhibitor
|
GDC-0980 (Apitolisib, GNE 390, RG 7422) is a potent, selective, orally available class I PI3K/mTOR inhibitor with IC50 of 5 nM/27 nM/7 nM/14 nM for PI3Kα/β/δ/γ, inhibits mTOR inhibitor with Ki of 17 nM. |
| PC-43336 |
Idelalisib
p110δ inhibitor
|
Idelalisib (CAL-101, GS-1101) is a potent, selective inhibitor of PI3K p110δ with IC50 of 2.5 nM, 40- to 300-fold selectivity over other class I PI3Ks (p110α/βγ, IC50=820/565/89nM), and 400- to 4000-fold over C2β, hVPS34, DNA-PK, and mTOR. |
| PC-43287 |
AMG319
PI3Kδ inhibitor
|
AMG319 (AMG-319) is a potent and selective PI3Kδ inhibitor with biochemical IC50 of 18 nM, displays >80-fold selectivity over PI3Kα/β/γ (IC50=3300/2700/850 nM). |
| PC-43269 |
AZD8835
PI3Kα/δ inhibitor
|
AZD8835 (AZD-8835) is a potent, selective inhibitor of PI3Kα and PI3Kδ with IC50 of 6.2 and 5.7 nM, 15-fold and >100-fold selectivity over PI3Kγ and PI3Kβ. |
| PC-43268 |
PQR309
PI3K/mTOR inhibitor
|
PQR309 (Bimiralisib) is a potent, brain-penetrant, orally bioavailable, pan-class I PI3K/mTOR inhibitor with IC50 of 33, 451, 661, 708 and 89 nM for PI3Kα, PI3Kδ, PI3Kβ, PI3Kγ and mTOR, respectively. |
| PC-43214 |
Vps34-IN-1
Vps34 inhibitor
|
Vps34-IN-1 is a potent, selective inhibitor of class III PI3K Vps34 with IC50 of 25 nM, does not inhibit class I and II PI3Ks, as well as a broad panel of protein kinases or lipid kinases. |
| PC-43213 |
Vps34 inhibitor PIK-III
Vps34 inhibitor
|
Vps34 inhibitor PIK-III (PIK-III) is a potent, selective inhibitor of Vps34 with IC50 of 18 nM, shows >100-fold selectivity over other class I PI3Ks, PI4Kβ and mTOR. |
| PC-43188 |
GNE-317
PI3K/mTOR inhibitor
|
GNE-317 (GNE317) is a potent, brain penepenetrant, dual PI3K/mTOR inhibitor having physicochemical properties predictive of low efflux by P-gp and BCRP. |
| PC-43131 |
Acalisib
p110δ inhibitor
|
Acalisib (GS-9820, CAL-120) is a potent, isoform-selective PI3K p110δ with IC50 of 12.7 nM, displays >100-fold selectivity over P110α/β/γ, and other class II/III PI3Ks, DNA-PK, mTOR. |
| PC-43082 |
LY3023414
PI3K/mTOR inhibitor
|
LY3023414 is a potent, dual PI3K/mTOR inhibitor with IC50 of 6.07 nM, 77.6 nM, 38 nM, 23.8 nM, 165 nM and 4.24 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ, mTOR and DNA-PK, respectively. |
