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Chemical Structure : RV-1729
Catalog No.: PC-63407Not For Human Use, Lab Use Only.
RV-1729 is a potent, selective PI3Kδ inhibitor with IC50 of 12 nM, 2-fold selectivity for PI3Kδ relative to PI3Kγ and 16-fold over PI3Kα.
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RV-1729 is a potent, selective PI3Kδ inhibitor with IC50 of 12 nM, 2-fold selectivity for PI3Kδ relative to PI3Kγ and 16-fold over PI3Kα.
RV-1729 inhibits PMA-induced peroxide production in U937 cells and phosphorylation of Akt in MCP1-stimulated THP1 cells with IC50 of 1.1 and 46 nM.
RV-1729 significantly inhibits allergen-induced responses in murine models of asthma and COPD.
| M.Wt | 735.242 | |
| Formula | C39H39ClN8O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Norman P. Expert Opin Ther Pat. 2014 Apr;24(4):471-5.
2. Respivert Ltd. Crystalline PI3 kinase inhibitors. WO2013136076; 2013
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