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RV-1729

Chemical Structure : RV-1729

CAS No.: 1293915-42-0

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RV-1729 (RV1729;RV 1729)

Catalog No.: PC-63407Not For Human Use, Lab Use Only.

RV-1729 is a potent, selective PI3Kδ inhibitor with IC50 of 12 nM, 2-fold selectivity for PI3Kδ relative to PI3Kγ and 16-fold over PI3Kα.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    RV-1729 is a potent, selective PI3Kδ inhibitor with IC50 of 12 nM, 2-fold selectivity for PI3Kδ relative to PI3Kγ and 16-fold over PI3Kα.
    RV-1729 inhibits PMA-induced peroxide production in U937 cells and phosphorylation of Akt in MCP1-stimulated THP1 cells with IC50 of 1.1 and 46 nM.
    RV-1729 significantly inhibits allergen-induced responses in murine models of asthma and COPD.

    Physicochemical Properties

    M.Wt 735.242
    Formula C39H39ClN8O5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    6-(2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-3-(2-chlorobenzyl)-4-oxo-3,4-dihydroquinazolin-5-yl)-N,N-bis(2-methoxyethyl)hex-5-ynamide

    References

    1. Norman P. Expert Opin Ther Pat. 2014 Apr;24(4):471-5.

    2. Respivert Ltd. Crystalline PI3 kinase inhibitors. WO2013136076; 2013

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