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Chemical Structure : BAY1082439
CAS No.: 1375469-38-7
Catalog No.: PC-63437Not For Human Use, Lab Use Only.
BAY1082439 is a potent, highly selective, orally available PI3Kα/β inhibitor with IC50 of 4.9 nM (PI3Kα), selectively inhibits both PI3Kα, including mutated forms of PIK3CA, and PI3Kβ in the PI3K/Akt/mTOR pathway.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $138 | In stock | |
| 25 mg | $238 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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BAY1082439 is a potent, highly selective, orally available PI3Kα/β inhibitor with IC50 of 4.9 nM (PI3Kα), selectively inhibits both PI3Kα, including mutated forms of PIK3CA, and PI3Kβ in the PI3K/Akt/mTOR pathway.
BAY1082439 displays >1000-fold selectivity against mTOR kinase.
BAY1082439 induces tumor cell apoptosis and growth inhibition in PI3K-expressing and/or PTEN-driven tumor cells.
BAY1082439 is more effective than PI3Kα- and/or PI3Kβ-selective inhibitors in blocking PTEN-null prostate cancer cells.
BAY1082439 effectively inhibits Pten-null prostate cancer progression
| M.Wt | 494.228 | |
| Formula | C25H30N6O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-N-(8-(2-hydroxy-3-morpholinopropoxy)-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)-2-methylnicotinamide |
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1. Ningshu Liu, et al. Abstract 2799: BAY 1082439, a highly selective and balanced PI3Kα/β inhibitor demonstrated potent activity in tumors with activated PI3Kα and loss-of-function of PTEN. Abstract nr 2799. doi:1538-7445.AM2012-2799.
2. Yongkang Zou, et al. Mol Cancer Ther. 2018 Oct;17(10):2091-2099.
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