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Cat. No. Product Name Information
PC-35788

hSMG-1 inhibitor 11e

hSMG-1 inhibitor

hSMG-1 inhibitor 11e is a potent, selective PI3K-related protein kinase hSMG-1 inhibitor with IC50 of <0.05 nM, >900-fold selectivity over mTOR, and no significant activity against CDK1/2.
PC-35745

LAS195319

PI3Kδ inhibitor

LAS195319 (LAS-195319) is a potent, selective, inhaled PI3Kδ inhibitor with IC50 of 0.5 nM, weakly inhibits PI3Kβ and γ (>20-fold), no activity against PI3Kα.
PC-35740

CYH33 methanesulfonate

PI3Kα inhibitor

CYH33 (Risovalisib) methanesulfonate is a novel potent, PI3Kα-selective inhibitor with IC50 of 5.9 nM/598 nM/ 78.7 nM/225 nM aginst class I PI3K isoform α/β/δ/γ, respectively.
PC-35739

CYH33

PI3Kα inhibitor

CYH33 (CYH-33) is a novel potent, PI3Kα-selective inhibitor with IC50 of 5.9 nM/598 nM/ 78.7 nM/225 nM aginst class I PI3K isoform α/β/δ/γ, respectively.
PC-35721

hSMG-1 inhibitor 11j

hSMG-1 inhibitor

hSMG-1 inhibitor 11j (SMG1i) is a potent, selective PI3K-related protein kinase hSMG-1 inhibitor with IC50 of 0.11 nM, 455-fold selectivity over mTOR and no activity against CDK1/2.
PC-35552

PQR-530

PI3K/mTOR inhibitor

PQR-530 (PQR530) is a potent, BBB penetrant, dual pan-PI3K/mTOR inhibitor with Kd of 0.3/1/6/11/10 nM for mTOR/PIK3CA/PIK3CB/PIK3CD/PIK3CG, respectively.
PC-35505

SB02024

Vps34 inhibitor

SB02024 is a novel highly potent, selective, ATP competitive, orally active inhibitor of vacuolar protein sorting 34 (Vps34) with Kd of 1 nM, >1000 times selective towards other PI3K isoenzymes.
PC-43503

NVP-BGT226

PI3K/mTOR inhibitor

NVP-BGT226 (BGT226) is a potent, dual PI3K/mTOR inhibitor with a preference for PI3Kα (wild type and mutated) and mTOR ( PI3Kα, PI3Kβ and PI3Kγ, IC50=4, 63 and 38 nM).
PC-43502

NVP-BAG956

PDK-1/PI3K inhibitor

NVP-BAG956 (BAG956) is a potent, dual PDK-1/PI3K inhibitor with IC50 of 245/56/446/35/117 nM for PDK1/p110α/p110β/p110δ/p110γ, respectively.
PC-43441

A66

p110α inhibitor

A66 (p110α inhibitor A66) is a potent, highly specific p110α inhibitor with IC50 of 32, 30 and 43 nM for wt p110α, p110α E545K and p110α H1047R, respectively.
PC-63437

BAY1082439

PI3Kα/β inhibitor

BAY1082439 is a potent, highly selective, orally available PI3Kα/β inhibitor with IC50 of 4.9 nM (PI3Kα), selectively inhibits both PI3Kα, including mutated forms of PIK3CA, and PI3Kβ in the PI3K/Akt/mTOR pathway.
PC-63407

RV-1729

PI3Kδ inhibitor

RV-1729 is a potent, selective PI3Kδ inhibitor with IC50 of 12 nM, 2-fold selectivity for PI3Kδ relative to PI3Kγ and 16-fold over PI3Kα.

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