| Cat. No. |
Product Name |
Information |
| PC-35745 |
LAS195319
PI3Kδ inhibitor
|
LAS195319 (LAS-195319) is a potent, selective, inhaled PI3Kδ inhibitor with IC50 of 0.5 nM, weakly inhibits PI3Kβ and γ (>20-fold), no activity against PI3Kα. |
| PC-35740 |
CYH33 methanesulfonate
PI3Kα inhibitor
|
CYH33 (Risovalisib) methanesulfonate is a novel potent, PI3Kα-selective inhibitor with IC50 of 5.9 nM/598 nM/ 78.7 nM/225 nM aginst class I PI3K isoform α/β/δ/γ, respectively. |
| PC-35739 |
CYH33
PI3Kα inhibitor
|
CYH33 (CYH-33) is a novel potent, PI3Kα-selective inhibitor with IC50 of 5.9 nM/598 nM/ 78.7 nM/225 nM aginst class I PI3K isoform α/β/δ/γ, respectively. |
| PC-35721 |
hSMG-1 inhibitor 11j
hSMG-1 inhibitor
|
hSMG-1 inhibitor 11j (SMG1i) is a potent, selective PI3K-related protein kinase hSMG-1 inhibitor with IC50 of 0.11 nM, 455-fold selectivity over mTOR and no activity against CDK1/2. |
| PC-35552 |
PQR-530
PI3K/mTOR inhibitor
|
PQR-530 (PQR530) is a potent, BBB penetrant, dual pan-PI3K/mTOR inhibitor with Kd of 0.3/1/6/11/10 nM for mTOR/PIK3CA/PIK3CB/PIK3CD/PIK3CG, respectively. |
| PC-35505 |
SB02024
Vps34 inhibitor
|
SB02024 is a novel highly potent, selective, ATP competitive, orally active inhibitor of vacuolar protein sorting 34 (Vps34) with Kd of 1 nM, >1000 times selective towards other PI3K isoenzymes. |
| PC-43503 |
NVP-BGT226
PI3K/mTOR inhibitor
|
NVP-BGT226 (BGT226) is a potent, dual PI3K/mTOR inhibitor with a preference for PI3Kα (wild type and mutated) and mTOR ( PI3Kα, PI3Kβ and PI3Kγ, IC50=4, 63 and 38 nM). |
| PC-43502 |
NVP-BAG956
PDK-1/PI3K inhibitor
|
NVP-BAG956 (BAG956) is a potent, dual PDK-1/PI3K inhibitor with IC50 of 245/56/446/35/117 nM for PDK1/p110α/p110β/p110δ/p110γ, respectively. |
| PC-43441 |
A66
p110α inhibitor
|
A66 (p110α inhibitor A66) is a potent, highly specific p110α inhibitor with IC50 of 32, 30 and 43 nM for wt p110α, p110α E545K and p110α H1047R, respectively. |
| PC-63437 |
BAY1082439
PI3Kα/β inhibitor
|
BAY1082439 is a potent, highly selective, orally available PI3Kα/β inhibitor with IC50 of 4.9 nM (PI3Kα), selectively inhibits both PI3Kα, including mutated forms of PIK3CA, and PI3Kβ in the PI3K/Akt/mTOR pathway. |
| PC-63407 |
RV-1729
PI3Kδ inhibitor
|
RV-1729 is a potent, selective PI3Kδ inhibitor with IC50 of 12 nM, 2-fold selectivity for PI3Kδ relative to PI3Kγ and 16-fold over PI3Kα. |
| PC-63379 |
Inavolisib
PI3Kα inhibitor
|
GDC-0077 (Inavolisib, RG-6114) is a potent, highly isoform selective inhibitor of PI3Kα, with IC50 of 0.038 nM. |
