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Chemical Structure : B591
Catalog No.: PC-35993Not For Human Use, Lab Use Only.
B591 (B-591) is a potent, specific pan-PI3K inhibitor with IC50 of 1.3/0.36/1.1/1.58 uM for PI3Kα/β/γ/δ, respectively.
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B591 (B-591) is a potent, specific pan-PI3K inhibitor with IC50 of 1.3/0.36/1.1/1.58 uM for PI3Kα/β/γ/δ, respectively.
B591 induces a dose-dependent decrease of PIP3/PI (4,5)P2 ratio with IC50 of 1.91 uM in HCT116 cells.
B591 shows effective inhibition of cellular PI3K/mTOR signaling pathway and robust antitumor activity in a set of cancer cell lines.
B591 exhibited more potency in suppressing cancer stem cells (CSCs) survival and inducing CSCs apoptosis, and presence of B591 effectively eliminated paclitaxel-enriched CSCs.
B591 preferentially decreases CSCs levels in mouse xenograft model of human breast cancer.
| M.Wt | 528.288 | |
| Formula | C25H24Br2N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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