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B591

Chemical Structure : B591

CAS No.:

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B591 (B-591;B 591)

Catalog No.: PC-35993Not For Human Use, Lab Use Only.

B591 (B-591) is a potent, specific pan-PI3K inhibitor with IC50 of 1.3/0.36/1.1/1.58 uM for PI3Kα/β/γ/δ, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    B591 (B-591) is a potent, specific pan-PI3K inhibitor with IC50 of 1.3/0.36/1.1/1.58 uM for PI3Kα/β/γ/δ, respectively.
    B591 induces a dose-dependent decrease of PIP3/PI (4,5)P2 ratio with IC50 of 1.91 uM in HCT116 cells.
    B591 shows effective inhibition of cellular PI3K/mTOR signaling pathway and robust antitumor activity in a set of cancer cell lines.
    B591 exhibited more potency in suppressing cancer stem cells (CSCs) survival and inducing CSCs apoptosis, and presence of B591 effectively eliminated paclitaxel-enriched CSCs.
    B591 preferentially decreases CSCs levels in mouse xenograft model of human breast cancer.

    Physicochemical Properties

    M.Wt 528.288
    Formula C25H24Br2N2O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    References

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