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BEBT-908

Chemical Structure : BEBT-908

CAS No.: 1235449-52-1

BEBT-908 (BEBT908;CUDC-908)

Catalog No.: PC-35868Not For Human Use, Lab Use Only.

BEBT-908 (BEBT908, CUDC-908) is a novel potent, dual PI3K/HDAC inhibitor with nanomolar IC50 values of <0.1 uM (PI3Kα) and 0.1-1 uM (HDAC).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BEBT-908 (BEBT908, CUDC-908) is a novel potent, dual PI3K/HDAC inhibitor with nanomolar IC50 values of <0.1 uM (PI3Kα) and 0.1-1 uM (HDAC).
BEBT-908 inhibited multiple pathways, including JAK/STAT3, MAPK/ERK and NF-κB, and induced apoptosis and cell cycle arrest at G1 phase in these cells.
Dual PI3K/HDAC inhibition via BEBT-908 is superior to the inhibition of PI3K or HDAC alone.

Physicochemical Properties

M.Wt 507.573
Formula C23H25N9O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-Pyrimidinecarboxamide, N-hydroxy-2-[methyl[[2-[6-(methylamino)-3-pyridinyl]-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl]amino]-

References

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