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Chemical Structure : CL27c
Catalog No.: PC-35887Not For Human Use, Lab Use Only.
CL27c is a cell-permeable, inhaled lipophilic ester prodrug of CL27e, which is a potent, selective pan-class I PI3K inhibitor, CL27c is inactive in PI3K enzymatic assay, once inside the cytoplasm, CL27c is metabolized by unspecific esterases into CL27e.
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CL27c is a cell-permeable, inhaled lipophilic ester prodrug of CL27e, which is a potent, selective pan-class I PI3K inhibitor.
CL27c is inactive in PI3K enzymatic assay, once inside the cytoplasm, CL27c is metabolized by unspecific esterases into CL27e.
CL27c readily reduces Akt/PKB phosphorylation in chronic lymphocytic leukemia (CLL) cells stimulated with anti-IgM antibodies, as well as in murine neutrophils and bone marrow-derived macrophages (BMDM) stimulated with C5a.
CL27c reduces insulin-evoked Akt phosphorylation in lungs, but no change in other tissues and no increase in blood glycaemia, in line with a local action.
CL27c reduces inflammation and improves lung function in murine models of acute or glucocorticoid-resistant neutrophilic asthma.
| M.Wt | 445.479 | |
| Formula | C24H23N5O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Campa CC, et al. Nat Commun. 2018 Dec 12;9(1):5232.
2. Pirali T, et al. ChemMedChem. 2017 Sep 21;12(18):1542-1554.
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