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CPL302-253

Chemical Structure : CPL302-253

CAS No.: 2019223-60-8

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CPL302-253 (CPL 302-253)

Catalog No.: PC-38318Not For Human Use, Lab Use Only.

CPL302-253 is a potent, selective inhibitor of PI3Kδ with IC50 of 12.2 nM and Kd of 0.83 nM, >350-fold selectivity over PI3K isoforms α, β, and γ (IC50>4,500 nM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CPL302-253 is a potent, selective inhibitor of PI3Kδ with IC50 of 12.2 nM and Kd of 0.83 nM, >350-fold selectivity over PI3K isoforms α, β, and γ (IC50>4,500 nM).
    CPL302-253 displays no off-target interaction in KinomeScan assays.
    CLP302-253 blocks activation of primary lymphoid cells in vitro, blocks IL-33 cytokine production in epithelial and T cell co-cultures.
    CLP302-253 bocks eosinophil infiltration to the lungs and IL-33 expression in HDM induced asthma mouse model.

    Physicochemical Properties

    M.Wt 474.613
    Formula C26H34N8O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 1 Month
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(2-((4-(tert-butyl)piperazin-1-yl)methyl)-5-(1H-pyrrolo[2,3-c]pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)morpholine

    References

    1. Paweł Gunerka, et al. PLoS One. 2020 Jul 23;15(7):e0236159.

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