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Chemical Structure : CPL302-253
Catalog No.: PC-38318Not For Human Use, Lab Use Only.
CPL302-253 is a potent, selective inhibitor of PI3Kδ with IC50 of 12.2 nM and Kd of 0.83 nM, >350-fold selectivity over PI3K isoforms α, β, and γ (IC50>4,500 nM).
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CPL302-253 is a potent, selective inhibitor of PI3Kδ with IC50 of 12.2 nM and Kd of 0.83 nM, >350-fold selectivity over PI3K isoforms α, β, and γ (IC50>4,500 nM).
CPL302-253 displays no off-target interaction in KinomeScan assays.
CLP302-253 blocks activation of primary lymphoid cells in vitro, blocks IL-33 cytokine production in epithelial and T cell co-cultures.
CLP302-253 bocks eosinophil infiltration to the lungs and IL-33 expression in HDM induced asthma mouse model.
| M.Wt | 474.613 | |
| Formula | C26H34N8O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Paweł Gunerka, et al. PLoS One. 2020 Jul 23;15(7):e0236159.
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