| Cat. No. |
Product Name |
Information |
| PC-20374 |
I-229
Vps34 inhibitor
|
I-229 is a potent and selective inhibitor of Vps34. |
| PC-20008 |
cyclo-CRVLIR
p110α/RAS inhibitor
|
cyclo-CRVLIR is a cyclic peptide that binds selectively to p110α RAS binding domain (p110α-RBD) with ITC Kd of 3 uM, blocks p110α/RAS interaction in vitro and KRAS cancer cell lines. |
| PC-49531 |
LL-00084282
PI3Kδ/γ inhibitor
|
LL-00084282 is a potent, selective and efficacious dual PI3Kδγ inhibitor with IC50 of 16.26 and 17.45 nM for PI3Kδ and PI3Kγ, respectively. |
| PC-49341 |
PITCOIN3
PI3KC2α inhibitor
|
PITCOIN3 is a potent, highly selective, cell-permeable inhibitor of PI3KC2α catalytic activity with IC50 of 126 nM. |
| PC-49266 |
LP-182
PI3K inhibitor
|
LP-182 (LP182) is a potent, selective and orally bioavailable multi-functional kinase inhibitor, specifically targets PI3K and MAPK signaling pathways. |
| PC-49141 |
CUDC-907
HDAC/PI3K inhibitor
|
Fimepinostat (CUDC-907) is a potent, dual-acting PI3K and HDAC inhibitor, potently inhibits HDAC classes I and II enzymes, inhibits class I PI3K kinases with IC50 of 19, 54, and 39 nM for PI3Kα, PI3Kβ, and PI3Kδ, respectively. |
| PC-49022 |
PF-06862309
PI3Kα inhibitor
|
PF-06862309 (PF-06843195 phosphate ester prodrug) is the in vivo-active, phosphate ester prodrug of PF-06843195, a potent selective PI3Kα inhibitor with Kd of <18 pM. |
| PC-49021 |
PF-06843195
PI3Kα inhibitor
|
PF-06843195 is a potent, selective PI3Kα inhibitor with Ki value of <0.018 nM, IC50 of 18 nM (RAT1 PI3Kα), with cellular isoform selectivity of 20-fold over PI3Kβ and 9-fold over PI3Kδ. |
| PC-38789 |
LL-00071210
PI3Kδ inhibitor
|
LL-00071210 is a potent, selective, orally bioavailable PI3Kδ inhibitor with IC50 values of 24.6 nM and 9.4 nM in biochemical and cellular assays, respectively. |
| PC-38687 |
HM5023507
PI3Kδ/γ inhibitor
|
HM5023507 is a potemt, selective, orally active dual PI3Kδ/γ inhibitor with IC50 of 4 nM and 5 nM for p110γ and p110δ, respectively. |
| PC-38686 |
AZD8154
PI3Kδ/γ inhibitor
|
AZD8154 is a highly potent, selective dual PI3Kγ/δ inhibitor with cell pIC50 of 9.1/8.4, respectively. |
| PC-38635 |
NVP-CLR457
class I PI3K inhibitor
|
NVP-CLR457 (CLR457) is a potent, orally bioavailable, non-CNS-penetrant pan-class I PI3K inhibitor with IC50 values of 89 nM, 56 nM, 39 nM and 230 nM for p110α, p110β, p110δ and p110γ isoforms, respectively. |
