| Cat. No. |
Product Name |
Information |
| PC-35993 |
B591
PI3K inhibitor
|
B591 (B-591) is a potent, specific pan-PI3K inhibitor with IC50 of 1.3/0.36/1.1/1.58 uM for PI3Kα/β/γ/δ, respectively. |
| PC-35887 |
CL27c
PI3K inhibitor
|
CL27c is a cell-permeable, inhaled lipophilic ester prodrug of CL27e, which is a potent, selective pan-class I PI3K inhibitor, CL27c is inactive in PI3K enzymatic assay, once inside the cytoplasm, CL27c is metabolized by unspecific esterases into CL27e. |
| PC-35880 |
SAR260301
PI3Kβ inhibitor
|
SAR260301 (SAR-260301, SAR 260301) is a potent, selective, ATP-competitive PI3Kβ inhibitor with IC50 of 52 nM in TR-FRET assays, with littile to no actiivty against PI3Kα/γ/δ (IC50=1,869/>10,000/403 nM, respectively). |
| PC-35868 |
BEBT-908
PI3K/HDAC inhibitor
|
BEBT-908 (BEBT908, CUDC-908) is a novel potent, dual PI3K/HDAC inhibitor with nanomolar IC50 values of <0.1 uM (PI3Kα) and 0.1-1 uM (HDAC). |
| PC-35788 |
hSMG-1 inhibitor 11e
hSMG-1 inhibitor
|
hSMG-1 inhibitor 11e is a potent, selective PI3K-related protein kinase hSMG-1 inhibitor with IC50 of <0.05 nM, >900-fold selectivity over mTOR, and no significant activity against CDK1/2. |
| PC-35745 |
LAS195319
PI3Kδ inhibitor
|
LAS195319 (LAS-195319) is a potent, selective, inhaled PI3Kδ inhibitor with IC50 of 0.5 nM, weakly inhibits PI3Kβ and γ (>20-fold), no activity against PI3Kα. |
| PC-35740 |
CYH33 methanesulfonate
PI3Kα inhibitor
|
CYH33 (Risovalisib) methanesulfonate is a novel potent, PI3Kα-selective inhibitor with IC50 of 5.9 nM/598 nM/ 78.7 nM/225 nM aginst class I PI3K isoform α/β/δ/γ, respectively. |
| PC-35739 |
CYH33
PI3Kα inhibitor
|
CYH33 (CYH-33) is a novel potent, PI3Kα-selective inhibitor with IC50 of 5.9 nM/598 nM/ 78.7 nM/225 nM aginst class I PI3K isoform α/β/δ/γ, respectively. |
| PC-35721 |
hSMG-1 inhibitor 11j
hSMG-1 inhibitor
|
hSMG-1 inhibitor 11j (SMG1i) is a potent, selective PI3K-related protein kinase hSMG-1 inhibitor with IC50 of 0.11 nM, 455-fold selectivity over mTOR and no activity against CDK1/2. |
| PC-35552 |
PQR-530
PI3K/mTOR inhibitor
|
PQR-530 (PQR530) is a potent, BBB penetrant, dual pan-PI3K/mTOR inhibitor with Kd of 0.3/1/6/11/10 nM for mTOR/PIK3CA/PIK3CB/PIK3CD/PIK3CG, respectively. |
| PC-35505 |
SB02024
Vps34 inhibitor
|
SB02024 is a novel highly potent, selective, ATP competitive, orally active inhibitor of vacuolar protein sorting 34 (Vps34) with Kd of 1 nM, >1000 times selective towards other PI3K isoenzymes. |
| PC-43503 |
NVP-BGT226
PI3K/mTOR inhibitor
|
NVP-BGT226 (BGT226) is a potent, dual PI3K/mTOR inhibitor with a preference for PI3Kα (wild type and mutated) and mTOR ( PI3Kα, PI3Kβ and PI3Kγ, IC50=4, 63 and 38 nM). |
