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Chemical Structure : IOA-244
CAS No.: 1305267-37-1
Catalog No.: PC-20591Not For Human Use, Lab Use Only.
IOA-244 (Roginolisib, MSC2360844) is a potent, selective and non-ATP-competitive PI3Kδ inhibitor with IC50 of 19 nM, selective over PI3Kβ (0.43 uM), Vps34 (9 uM) and PI3Kα (10.1 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $488 | In stock | |
| 100 mg | Get quote |
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IOA-244 (Roginolisib, MSC2360844) is a potent, selective and non-ATP-competitive PI3Kδ inhibitor with IC50 of 19 nM, selective over PI3Kβ (0.43 uM), Vps34 (9 uM) and PI3Kα (10.1 uM).
IOA-244 effectively inhibits proliferation of SU-DHL-6 (PI3Kδ harboring) with a GI50 of 0.24 uM.
IOA-244 limits proliferation of lymphoma cancer cells expressing high levels of PI3Kδ.
IOA-244 inhibits regulatory T cell proliferation while having limited antiproliferative effects on conventional CD4+ T cells and no effect on CD8+ T cells.
IOA-244 sensitized the tumors to anti-PD-1 treatment in CT26 colorectal and Lewis lung carcinoma lung cancer models, with similar activity in the Pan-02 pancreatic and A20 lymphoma syngeneic mouse models.
| M.Wt | 526.58 | |
| Formula | C26H27FN4O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(6-fluoro-1-(4-(morpholinomethyl)phenyl)-5,5-dioxido-1,4-dihydrothiochromeno[4,3-c]pyrazol-3-yl)(morpholino)methanone |
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1. Haselmayer P, et al. Front Immunol 2014;5:233.
2. Johnson Z, et al. Cancer Res Commun. 2023 Apr 14;3(4):576-591.
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