Zandelisib | p110δ inhibitor | Probechem Biochemicals

Chemical Structure : Zandelisib

CAS No.: 1401436-95-0

Zandelisib (ME-401, PWT-143)

Catalog No.: PC-20568Not For Human Use, Lab Use Only.

Zandelisib (ME-401, PWT-143) is a potent, selective and orally active inhibitor of phosphatidylinositol 3 kinase p110δ with IC50 of 3.5 nM.

Packing	Price	Stock
5 mg	$228	In stock
25 mg	$498	In stock
50 mg	$758	In stock
100 mg	$1280	In stock
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Biological Activity

Zandelisib (ME-401, PWT-143) is a potent, selective and orally active inhibitor of phosphatidylinositol 3 kinase p110δ with IC50 of 3.5 nM.
Zandelisib inhibits PI3Ks with IC50s of 4, 976 nM, 605 nM, 817 nM and 3.5 nM for p110α, p110β, p110γ and p110δ, respectivey.

Physicochemical Properties

M.Wt	576.68
Formula	C31H38F2N8O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	CN1CCC(C2=CC=CC=C2CC(NC3=NC(N4C5=CC=CC=C5N=C4C(F)F)=NC(N6CCOCC6)=N3)(C)C)CC1

References

1. Moreno O, et al. Clin Ther. 2018 Nov;40(11):1855-1867.

2. Patent WO2019183226A1.

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Zandelisib (ME-401, PWT-143)

Biological Activity

Physicochemical Properties

References

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