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PI3Kβ inhibitor (P)-14

Chemical Structure : PI3Kβ inhibitor (P)-14

CAS No.: 2213418-22-3

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PI3Kβ inhibitor (P)-14

Catalog No.: PC-20468Not For Human Use, Lab Use Only.

PI3Kβ inhibitor (P)-14 is a potent, highly selective and orally bioavailable PI3Kβ inhibitor with IC50 of 2 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PI3Kβ inhibitor (P)-14 is a potent, highly selective and orally bioavailable PI3Kβ inhibitor with IC50 of 2 nM.
    PI3Kβ inhibitor (P)-14 inhibits the phosphorylation of AKT (AKT1 ser473) in PTEN-deficient tumor cell lines with EC50 of 5-30 nM.

    Physicochemical Properties

    M.Wt 464.44
    Formula C25H14F2N8
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-[1-(5,8-Difluoro-4-quinolinyl)-2-methyl-4-(1H-1,2,4-triazol-5-yl)-1H-benzimidazol-6-yl]-2-pyridinecarbonitrile

    References

    1. Stephane Perreault, et al. ACS Med Chem Lett. 2020 Apr 13;11(6):1236-1243.

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