| Cat. No. |
Product Name |
Information |
| PC-62843 |
PI3Kα-IN-4h
PI3Kα inhibitor
|
PI3Kα-IN-4h is a potent, selective, ATP-competitive dual PI3Kα/mTOR inhibitor with IC50 of 0.5/104 nM respectively. |
| PC-62838 |
PI3Kα-IN-5
PI3Kα inhibitor
|
PI3Kα-IN-5 is a potent, selective PI3Kα inhibitor with enzyme IC50 and cell IC50 of 6 nM and 87 nM respectively, exhibits 100-fold selectivity over PI3Kβ. |
| PC-62830 |
PI3K-IN-8q
p110α/p110δ inhibitor
|
PI3K-IN-8q is a potent, selective dual p110α/p110δ inhibitor with Ki app of 3.3/8.36 nM respectively. |
| PC-62806 |
PI3Kδ-IN-7n
PI3Kδ inhibitor
|
PI3Kδ-IN-7n is a highly potent and selective PI3Kδ inhibitor with IC50 of 0.9 nM, displays high selectivity (>1,500-fold) over PI3Kα, PI3Kβ, PI3Kγ (IC50>1.5 uM). |
| PC-62708 |
PI3K-IN-16
PI3Kβ/δ inhibitor
|
PI3K-IN-16 is a potent and selective, orally bioavailable PI3Kβ and PI3Kδ inhibitor with cell IC50 of 12 nM (in PTEN null MDA-MB-468 cell) and 47 nM (in Jeko-1 B-cell), respectively. |
| PC-61959 |
DS-7423
PI3K/mTOR inhibitor
|
DS-7423 is a novel potent, small-molecule dual inhibitor of PI3K/mTOR with IC50 of 15.6, 1143, 249, 262 and 34.9 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, and mTOR respectively. |
| PC-61742 |
ST-162
MAPK/PI3K inhibitor
|
ST-162 is a potent, bifunctional MAPK/PI3K antagonist with IC50 of 191 nM and 398 nM for PI3Kα and MEK1, respectively. |
| PC-61741 |
ST-168
MEK/PI3K inhibitor
|
ST-168 is a novel potent, orally available MEK/PI3K bifunctional inhibitor with IC50 of 182, 69.2, 1482, 2293, and 41.7 nM for MEK1, PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, respectively. |
| PC-61135 |
PI3Kβ/δ inhibitor 20a
PI3Kβ/δ inhibitor
|
PI3Kβ/δ inhibitor 20a is a potent, highly selective PI3Kβ/δ inhibitor with IC50 of 7.8/5.3 nM respectively, with liitle to no activity on PI3Kα/γ (IC50=850/>10,000 nM). |
| PC-61127 |
PI3Kδ inhibitor 52
|
ZUN64390 is a potent, selective, and efficacious PI3Kδ inhibitor with IC50 of 1.7 nM, >100-fold selectivitity over PI3Kγ/α/β. |
| PC-60983 |
AMG511
PI3K inhibitor
|
AMG511 (AMG-511) potent, efficacious, and orally available pan class I PI3K inhibitor with Ki of 4/6/2/1 nM for PI3Kα/β/δ/γ, respectively. |
| PC-60567 |
Tenalisib
p110δ/γ inhibitor
|
Tenalisib (RP-6530) is a potent, selective, orally active p110δ/γ PI3K dual inhibitor with IC50 of 24.5 and 33.2 nM, respectively. |
