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PI3K-IN-16

Chemical Structure : PI3K-IN-16

CAS No.: 1895876-81-9

PI3K-IN-16 (PI3Kβ/δ inhibitor)

Catalog No.: PC-62708Not For Human Use, Lab Use Only.

PI3K-IN-16 is a potent and selective, orally bioavailable PI3Kβ and PI3Kδ inhibitor with cell IC50 of 12 nM (in PTEN null MDA-MB-468 cell) and 47 nM (in Jeko-1 B-cell), respectively.

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    Biological Activity

    PI3K-IN-16 is a potent and selective, orally bioavailable PI3Kβ and PI3Kδ inhibitor with cell IC50 of 12 nM (in PTEN null MDA-MB-468 cell) and 47 nM (in Jeko-1 B-cell), respectively.
    PI3K-IN-16  exhibits no significant activity on PI3Kα.
    PI3K-IN-16  shows profound pharmacodynamic modulation of AKT phosphorylation, excellent tumour growth inhibition in a mouse PTEN-deficient PC3 prostate tumour xenograft.

    Physicochemical Properties

    M.Wt 467.497
    Formula C25H26FN3O5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    8-((8-fluoro-2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl)methyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide

    References

    1. Barlaam B, et al. Bioorg Med Chem Lett. 2016 May 1;26(9):2318-23.

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