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GNE-293

Chemical Structure : GNE-293

CAS No.: 1354955-67-1

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GNE-293 (GNE293)

Catalog No.: PC-62886Not For Human Use, Lab Use Only.

GNE-293 is a potent and selective PI3Kδ inhibitor with Ki of 0.47 nM, displays 256, 420, 219-fold selectivity over PI3Kα, PI3Kβ, PI3Kγ, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    GNE-293 is a potent and selective PI3Kδ inhibitor with Ki of 0.47 nM, displays 256, 420, 219-fold selectivity over PI3Kα, PI3Kβ, PI3Kγ, respectively。
    GNE-293 exhibits excellent potency in human whole blood (HWB) assay (CD69 HWB IC50=4.38 nM)。
    GNE-293 possesses favorable pharmacokinetic properties and orally bioavailable.

    Physicochemical Properties

    M.Wt 580.708
    Formula C28H36N8O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(3-((2-(2-isopropyl-1H-benzo[d]imidazol-1-yl)-9-methyl-6-morpholino-9H-purin-8-yl)oxy)azetidin-1-yl)tetrahydro-2H-thiopyran 1,1-dioxide

    References

    1. Safina BS, et al. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4953-9.

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