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PI3K-IN-8q

Chemical Structure : PI3K-IN-8q

CAS No.: 1280204-67-2

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PI3K-IN-8q (p110α/p110δ inhibitor)

Catalog No.: PC-62830Not For Human Use, Lab Use Only.

PI3K-IN-8q is a potent, selective dual p110α/p110δ inhibitor with Ki app of 3.3/8.36 nM respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PI3K-IN-8q is a potent, selective dual p110α/p110δ inhibitor with Ki app of 3.3/8.36 nM respectively.
    PI3K-IN-8q exhibits high selectivity over p110α and p110β (Ki>490 nM); inhibits p-Akt with EC50 of 50 nM, and p110α with IC50 of 0.5 nM.
    PI3K-IN-8q has promising in vivo PK data; orally bioavailable.

    Physicochemical Properties

    M.Wt 446.49
    Formula C23H23FN8O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-(2-(4-fluorophenyl)-9-morpholino-1,2,3,4-tetrahydropyrido[3',4':4,5]imidazo[1,2-a]pyrazin-7-yl)pyrimidin-2-amine

    References

    1. Martínez González S, et al. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2536-2543.

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