| Cat. No. |
Product Name |
Information |
| PC-45869 |
ZSTK474
PI3K inhibitor
|
ZSTK474 (ZSTK-474) is a potent inhibitor of class I PI3K isoforms with IC50 of 17 nM, 53 nM, and 6 nM for p110β, p110γ, and p110δ, respectively. |
| PC-42695 |
PKI-402
PI3K/mTOR inhibitor
|
PKI-402 is a potent dual PI3K/mTOR inhibitor with IC50 of 1/7/16/14/1.7 nM for PI3Kα/β/γ/δ/mTOR respectively. |
| PC-42315 |
IC-87114
PI3Kδ inhibitor
|
IC-87114 (IC87114) is a potent and selective PI3Kδ inhibitor with IC50 of 0.5 uM. |
| PC-42326 |
SF2523
PI3K/BRD4 inhibitor
|
SF2523 is a potent, dual inhibitor of PI3K and BRD4 with IC50 of 241, 34, 158 nM for BRD4 (BD1), PI3Kα and PI3Kγ, respectively. |
| PC-45394 |
Leniolisib
PI3Kδ inhibitor
|
Leniolisib (CDZ173) is a potent and selective PI3Kδ inhibitor with biochemical IC50 of 11 nM. |
| PC-42518 |
PIK-294
p110δ inhibitor
|
PIK-294 is a highly potent, selective p110δ inhibitor with IC50 of 10 nM, shows 1000-, 49- and 16-fold less potent to PI3Kα/β/γ. |
| PC-42513 |
Omipalisib
PI3K/mTOR inhibitor
|
Omipalisib (GSK2126458) is a highly potent dual inhibitor PI3K/mTOR inhibitor with app Ki of 19/130/24/60/180/300 nM for p110α/p110β/p110γ/p110δ/mTORC1/mTORC2 respectively. |
| PC-42133 |
PF-04979064
PI3K/mTOR inhibitor
|
PF-04979064 is a highly potent and selective, dual PI3K/mTOR inhibitor with Ki of 0.13, 0.111, 0.122 and 1.42 nM for PI3Kα, PI3Kγ, PI3Kδ and mTOR, respectively. |
| PC-42310 |
LY294002
PI3K inhibitor
|
LY294002 is a classic, broad-spectrum PI3K inhibitor with IC50 of 0.5/0.57/0.97 uM for PI3Kα/δ/β, respectively. |
| PC-23844 |
PF-04691502
PI3K/mTOR inhibitor
|
PF-04691502 is a potent, selective, ATP-competitive PI3K/mTOR dual inhibitor with Ki of 1.8/1.2 nM (human/mouse PI3Kα), 2.1/1.6/1.9 nM (PI3Kβ/δ/γ) and 16 nM (human mTOR). |
| PC-23786 |
VVD-844
p110α RBD inhibitor
|
VVD-844 is a specific, covalent inhibitor of RAS binding domain of PI3Kα (p110α RBD), disrupts the RAS-p110α interaction, binds covalently to Cys242 in p110α RBD and blocks the ability of RAS to activate PI3K activity. |
| PC-23785 |
VVD-699
p110α RBD inhibitor
|
VVD-699 is a specific, covalent inhibitor of RAS binding domain of PI3Kα (p110α RBD), disrupts the RAS-p110α interaction, binds covalently to Cys242 in p110α RBD and blocks the ability of RAS to activate PI3K activity. |
