| Cat. No. |
Product Name |
Information |
| PC-73420 |
Gilmelisib
PI3K inhibitor
|
Gilmelisib is a potent PI3K inhibitor with IC50 of <1 nM for PI3K p110α, exhibits antineoplastic acitvity. |
| PC-73277 |
PQR514
PI3K inhibitor
|
PQR514 is a potent selective pan-PI3K inhibitor with binding Ki of 2.2 and 33 nM for p110α and mTOR, repectively. |
| PC-72781 |
GSK251
PI3Kδ inhibitor
|
GSK251 is a highly potent, selective, orally bioavailable inhibitor of PI3Kδ with pKi of 10.9, >1,000-fold selectivity over other PI3K isoforms. |
| PC-72075 |
FAPL-PI3Ki1
FAP-targeted PI3K inhibitor
|
FAPL-PI3Ki1 is a specific FAP-targeted PI3K inhibitor that selectively targets FAP-expressing human IPF lung fibroblasts and potently inhibits collagen synthesis. |
| PC-42943 |
TGR-1202 R-enantiomer
|
TGR-1202 R-enantiomer is is the less active enantiomer of TGR-1202 (Umbralisib), TGR-1202 is a potent, selective, orally available PI3Kδ inhibitor with IC50 of 22 nM.. |
| PC-42881 |
PI3K-IN-1
|
PI3K-IN-1 is a potent inhibitor of PI3K, extracted from patent WO2012103524 A2 and WO2013147649 A2.. |
| PC-42812 |
PI3K inhibitor X
|
PI3K inhibitor X (XL-147 analog) is a derivative of XL147 that acts as a reversible inhibitor of class I PI3Ks with IC50 of 39, 36, 23 and 383 nM for p110α, δ, γ and β respectively. |
| PC-62843 |
PI3Kα-IN-4h
|
PI3Kα-IN-1 is a potent, selective, ATP-competitive dual PI3Kα/mTOR inhibitor with IC50 of 0.5/104 nM respectively. |
| PC-62838 |
PI3Kα-IN-5
|
PI3Kα-IN-5 is a potent, selective PI3Kα inhibitor with enzyme IC50 and cell IC50 of 6 nM and 87 nM respectively, exhibits 100-fold selectivity over PI3Kβ. |
| PC-62830 |
PI3K-IN-8q
|
PI3K-IN-8q is a potent, selective dual p110α/p110δ inhibitor with Ki app of 3.3/8.36 nM respectively. |
| PC-62806 |
PI3Kδ-IN-7n
|
PI3Kδ-IN-7n is a highly potent and selective PI3Kδ inhibitor with IC50 of 0.9 nM, displays high selectivity (>1,500-fold) over PI3Kα, PI3Kβ, PI3Kγ (IC50>1.5 uM). |
| PC-62708 |
PI3K-IN-16
|
PI3K-IN-16 is a potent and selective, orally bioavailable PI3Kβ and PI3Kδ inhibitor with cell IC50 of 12 nM (in PTEN null MDA-MB-468 cell) and 47 nM (in Jeko-1 B-cell), respectively. |
