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Chemical Structure : Dactolisib
CAS No.: 915019-65-7
Catalog No.: PC-45837Not For Human Use, Lab Use Only.
Dactolisib (NVP-BEZ235) is a potent, dual ATP-competitive pan-class I PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $88 | In stock | |
| 100 mg | $148 | In stock | |
| 200 mg | $248 | In stock | |
| 1 g | Get quote |
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Dactolisib (NVP-BEZ235) is a potent, dual ATP-competitive pan-class I PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM, respectively.
Dactolisib (NVP-BEZ235) effectively and specifically blocks the dysfunctional activation of the PI3K pathway, inducing G(1) arrest; demonstrates antitumor activity in in vivo models of human cancer.
| M.Wt | 469.5365 | |
| Formula | C30H23N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 8.75 mg/mL |
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| Chemical Name/SMILES |
Benzeneacetonitrile, 4-[2,3-dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo[4,5-c]quinolin-1-yl]-.alpha.,.alpha.-dimethyl- |
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1. Maira SM, et al. Mol Cancer Ther. 2008 Jul;7(7):1851-63.
2. Serra V, et al. Cancer Res. 2008 Oct 1;68(19):8022-30.
3. Schnell CR, et al. Cancer Res. 2008 Aug 15;68(16):6598-607.
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