Catalog No.: PC-45837Not For Human Use, Lab Use Only.
Dactolisib (NVP-BEZ235) is a potent, dual ATP-competitive pan-class I PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM, respectively.
Dactolisib (NVP-BEZ235) is a potent, dual ATP-competitive pan-class I PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM, respectively.
Dactolisib (NVP-BEZ235) effectively and specifically blocks the dysfunctional activation of the PI3K pathway, inducing G(1) arrest; demonstrates antitumor activity in in vivo models of human cancer.
