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Chemical Structure : PKI-402
CAS No.: 1173204-81-3
Catalog No.: PC-42695Not For Human Use, Lab Use Only.
PKI-402 is a potent dual PI3K/mTOR inhibitor with IC50 of 1/7/16/14/1.7 nM for PI3Kα/β/γ/δ/mTOR respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $378 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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PKI-402 is a potent dual PI3K/mTOR inhibitor with IC50 of 1/7/16/14/1.7 nM for PI3Kα/β/γ/δ/mTOR respectively.
PKI-402 shows excellent suppression of Akt T308 phosphorylation (IC50=5 nM), and excellent inhibition of cell proliferation in several human cancer cell lines.
PKI-402 shows excellent in vivo efficacy in various human cancer xenografts, good physical properties and PK parameters.
| M.Wt | 570.6454 | |
| Formula | C29H34N10O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: < 1 mg/mL |
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| Chemical Name/SMILES |
Urea, N-[4-[3-ethyl-7-(4-morpholinyl)-3H-1,2,3-triazolo[4,5-d]pyrimidin-5-yl]phenyl]-N'-[4-[(4-methyl-1-piperazinyl)carbonyl]phenyl]- |
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1. Dehnhardt CM, et al. J Med Chem. 2010 Jan 28;53(2):798-810.
2. Mallon R, et al. Mol Cancer Ther. 2010 Apr;9(4):976-84.
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