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Chemical Structure : PI-103
CAS No.: 371935-74-9
Catalog No.: PC-42328Not For Human Use, Lab Use Only.
PI-103 is a potent, dual class I PI3K/mTOR inhibitor with IC50 of 2/3/3/15/ for p110α/β/δ/γ, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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PI-103 is a potent, dual class I PI3K/mTOR inhibitor with IC50 of 2/3/3/15/ for p110α/β/δ/γ, respectively.
PI-103 also inhibits TORC1 (>80% inhibition at 0.5 uM) and DNA-PK (IC50=14 nM), 15- to 20-fold less activity against class II PI3K C2β (IC50=43 nM), >1,300-fold selectivity over the class III PI3K Vsp34.
PI-103 potently inhibits proliferation and invasion of a wide variety of human cancer cells in vitro.
PI-103 shows activity in cancer xenograft models.
| M.Wt | 348.3553 | |
| Formula | C19H16N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Phenol, 3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]- |
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1. Fan QW, et al. Cancer Cell. 2006 May;9(5):341-9.
2. Raynaud FI, et al. Cancer Res. 2007 Jun 15;67(12):5840-50.
3. Fan QW, et al. Cancer Res. 2007 Sep 1;67(17):7960-5.
4. Kojima K, et al. Leukemia. 2008 Sep;22(9):1728-36.
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