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Chemical Structure : SF2523
CAS No.: 1174428-47-7
Catalog No.: PC-42326Not For Human Use, Lab Use Only.
SF2523 is a potent, dual inhibitor of PI3K and BRD4 with IC50 of 241, 34, 158 nM for BRD4 (BD1), PI3Kα and PI3Kγ, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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SF2523 is a potent, dual inhibitor of PI3K and BRD4 with IC50 of 241, 34, 158 nM for BRD4 (BD1), PI3Kα and PI3Kγ, respectively.
SF2523 interacts robustly with the full-length BRD4 (Kd=140 nM) and BRD4(BD1) (Kd=150 nM), binds more weakly BRD4(BD2) (Kd = 710 nM).
SF2523 blocks MYC expression and activation, promotes MYC degradation, and markedly inhibits cancer cell growth and metastasis both in vitro and in vivo.
| M.Wt | 371.40698 | |
| Formula | C19H17NO5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 30 mg/mL |
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| Chemical Name/SMILES |
7H-Thieno[3,2-b]pyran-7-one, 3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-(4-morpholinyl)- |
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1. Andrews FH, et al. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):E1072-E1080.
2. Carlino L, et al. J Med Chem. 2016 Oct 27;59(20):9305-9320.
3. Shen G, et al. Biochem Biophys Res Commun. 2017 Nov 10. pii: S0006-291X(17)32240-4.
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