ZSTK474 | PI3K inhibitor | Probechem Biochemicals

Chemical Structure : ZSTK474

CAS No.: 475110-96-4

ZSTK474 (ZSTK 474, ZSTK 474)

Catalog No.: PC-45869Not For Human Use, Lab Use Only.

ZSTK474 (ZSTK-474) is a potent inhibitor of class I PI3K isoforms with IC50 of 17 nM, 53 nM, and 6 nM for p110β, p110γ, and p110δ, respectively.

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25 mg	$98	In stock
50 mg	$148	In stock
100 mg	$238	In stock
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Biological Activity

ZSTK474 (ZSTK-474) is a potent inhibitor of class I PI3K isoforms with IC50 of 17 nM, 53 nM, and 6 nM for p110β, p110γ, and p110δ, respectively.
ZSTK474 (ZSTK474) shows potent antiproliferative activity against a panel of 39 human cancer cell lines with mean GI50 of 0.32 uM.
ZSTK474 (ZSTK474) is more effectively than that of LY294002 or wortmannin.
ZSTK474 (ZSTK474) induces apoptosis in OVCAR3 cells, and induces complete G1-phase arrest but not apoptosis in A549 cells at 10 uM.
ZSTK474 (ZSTK474) completely inhibits the growth of A549, PC-3, and WiDr xenografts in mice at 400mg/kg; and induces the regression of A549 xenograft tumors.

Physicochemical Properties

M.Wt	417.4125
Formula	C19H21F2N7O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Benzimidazole, 2-(difluoromethyl)-1-(4,6-di-4-morpholinyl-1,3,5-triazin-2-yl)-

References

1. Yaguchi S, et al. J Natl Cancer Inst, 2006, 98(8), 545-556.

2. Kong D, et al. Cancer Sci, 2007, 98(10), 1638-1642.

3. Kong D, et al. Eur J Cancer, 2009, 45(5), 857-865.

ZSTK474 (ZSTK 474, ZSTK 474)

Biological Activity

Physicochemical Properties

References

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