IC-87114 |CAS:371242-69-2 Probechem Biochemicals

Chemical Structure : IC-87114

CAS No.: 371242-69-2

IC-87114 (IC87114;IC 87114)

Catalog No.: PC-42315Not For Human Use, Lab Use Only.

IC-87114 (IC87114) is a potent and selective PI3Kδ inhibitor with IC50 of 0.5 uM.

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25 mg	$198	In stock
50 mg	$298	In stock
100 mg	$498	In stock
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Biological Activity

IC-87114 (IC87114) is a potent and selective PI3Kδ inhibitor with IC50 of 0.5 uM.
IC-87114 displays 58-fold selectivity over PI3Kγ, and >100-fold over PI3Kα and PI3Kβ.
IC-87114 inhibits polarized morphology of neutrophils, fMLP-stimulated PIP3 production and chemotaxis.
IC-87114 inhibits constitutive phosphorylation of Akt/PKB and suppresses AML cell proliferation.
IC-87114 reduces vascular permeability in a murine model of asthma.

Physicochemical Properties

M.Wt	397.4326
Formula	C22H19N7O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4(3H)-Quinazolinone, 2-[(6-amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-

References

1. Sadhu C, et al. J Immunol. 2003 Mar 1;170(5):2647-54.

2. Billottet C, et al. Oncogene. 2006 Oct 26;25(50):6648-59.

3. Puri KD, et al. Blood. 2004 May 1;103(9):3448-56.

4. Lee KS, et al. J Allergy Clin Immunol. 2006 Aug;118(2):403-9.

IC-87114 (IC87114;IC 87114)

Biological Activity

Physicochemical Properties

References

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