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Chemical Structure : IC-87114
CAS No.: 371242-69-2
Catalog No.: PC-42315Not For Human Use, Lab Use Only.
IC-87114 (IC87114) is a potent and selective PI3Kδ inhibitor with IC50 of 0.5 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $498 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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IC-87114 (IC87114) is a potent and selective PI3Kδ inhibitor with IC50 of 0.5 uM.
IC-87114 displays 58-fold selectivity over PI3Kγ, and >100-fold over PI3Kα and PI3Kβ.
IC-87114 inhibits polarized morphology of neutrophils, fMLP-stimulated PIP3 production and chemotaxis.
IC-87114 inhibits constitutive phosphorylation of Akt/PKB and suppresses AML cell proliferation.
IC-87114 reduces vascular permeability in a murine model of asthma.
| M.Wt | 397.4326 | |
| Formula | C22H19N7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4(3H)-Quinazolinone, 2-[(6-amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)- |
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1. Sadhu C, et al. J Immunol. 2003 Mar 1;170(5):2647-54.
2. Billottet C, et al. Oncogene. 2006 Oct 26;25(50):6648-59.
3. Puri KD, et al. Blood. 2004 May 1;103(9):3448-56.
4. Lee KS, et al. J Allergy Clin Immunol. 2006 Aug;118(2):403-9.
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