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Chemical Structure : Wortmannin
CAS No.: 19545-26-7
Catalog No.: PC-42442Not For Human Use, Lab Use Only.
Wortmannin (SL-2052, KY-12420) is a potent PI3K inhibitor with IC50 of 3 nM, does not inhibit PI4K activity.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $138 | In stock | |
| 25 mg | $228 | In stock | |
| 50 mg | $388 | In stock | |
| 100 mg | Get quote |
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Wortmannin (SL-2052, KY-12420) is a potent PI3K inhibitor with IC50 of 3 nM, does not inhibit PI4K activity.
Wortmannin inhibits both Fc epsilon RI-mediated histamine secretion and leukotriene release up to 80% with IC50 of 2.0 and 3.0 nM, respectively.
Wortmannin also inhibits DNA-PK and MLCK.
| M.Wt | 428.4319 | |
| Formula | C23H24O8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3H-Furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6,9-trione, 11-(acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-, (1S,6bR,9aS,11R,11bR)- |
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1. Yano H, et al. J Biol Chem. 1993 Dec 5;268(34):25846-56.
2. Nakanishi S, et al. J Biol Chem. 1992 Feb 5;267(4):2157-63.
3. Nakanishi S, et al. J Biol Chem. 1994 Mar 4;269(9):6528-35.
4. Boulton S, et al. Carcinogenesis. 1996 Nov;17(11):2285-90.
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