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PI3Kδ-IN-7n

Chemical Structure : PI3Kδ-IN-7n

CAS No.: 2088525-31-7

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PI3Kδ-IN-7n

Catalog No.: PC-62806Not For Human Use, Lab Use Only.

PI3Kδ-IN-7n is a highly potent and selective PI3Kδ inhibitor with IC50 of 0.9 nM, displays high selectivity (>1,500-fold) over PI3Kα, PI3Kβ, PI3Kγ (IC50>1.5 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PI3Kδ-IN-7n is a highly potent and selective PI3Kδ inhibitor with IC50 of 0.9 nM, displays high selectivity (>1,500-fold) over PI3Kα, PI3Kβ, PI3Kγ (IC50>1.5 uM).
PI3Kδ-IN-7n shows reasonable pharmacokinetics with good bioavailability and moderate in vivo half-life.
PI3Kδ-IN-7n is one of the most selective PI3Kδ inhibitors published to date.

Physicochemical Properties

M.Wt 429.459
Formula C23H20FN7O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(3-amino-6-(1-methyl-5-(1-phenylcyclopropyl)-1H-1,2,4-triazol-3-yl)pyrazin-2-yl)-2-fluorobenzamide

References

1. Terstiege I, et al. Bioorg Med Chem Lett. 2017 Feb 1;27(3):679-687.

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