PITCOIN2 | PI3KC2α inhibitor | Probechem Biochemicals

Chemical Structure : PITCOIN2

PITCOIN2 (LU-06-006)

Catalog No.: PC-20451Not For Human Use, Lab Use Only.

PITCOIN2 (LU-06-006) is a potent selective PI3KC2α inhibitor with IC50 of 126 nM, has selectivity against PI3KC2γ but shows micromolar activity on PI3KC2β.

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Biological Activity

PITCOIN2 (LU-06-006) is a potent selective PI3KC2α inhibitor with IC50 of 126 nM, has selectivity against PI3KC2γ but shows micromolar activity on PI3KC2β.

Physicochemical Properties

M.Wt	516.59
Formula	C25H20N6O3S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(3-hydroxyphenyl)thiazol-2-yl)-2-((4-oxo-3-phenethyl-3,4-dihydropteridin-2-yl)thio)acetamide

References

1. Lo WT, et al. Nat Chem Biol. 2023 Jan;19(1):18-27.

2. Patent WO2019234237 A1.

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PITCOIN2 (LU-06-006)

Biological Activity

Physicochemical Properties

References

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