PQR-530 |CAS:1927857-61-1 Probechem Biochemicals

Chemical Structure : PQR-530

CAS No.: 1927857-61-1

PQR-530 (PQR530, PQR 530)

Catalog No.: PC-35552Not For Human Use, Lab Use Only.

PQR-530 (PQR530) is a potent, BBB penetrant, dual pan-PI3K/mTOR inhibitor with Kd of 0.3/1/6/11/10 nM for mTOR/PIK3CA/PIK3CB/PIK3CD/PIK3CG, respectively.

Packing	Price	Stock
5 mg	$158	In stock
10 mg	$238	In stock
25 mg	$398	In stock
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Biological Activity

PQR-530 (PQR530) is a potent, BBB penetrant, dual pan-PI3K/mTOR inhibitor with Kd of 0.3/1/6/11/10 nM for mTOR/PIK3CA/PIK3CB/PIK3CD/PIK3CG, respectively.
PQR-530 effectively cross the blood-brain barrier and increase seizure threshold in a mouse model of chronic epilepsy.

Physicochemical Properties

M.Wt	407.42
Formula	C18H23F2N7O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-4-(difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine

References

1. Brandt C, et al. Neuropharmacology. 2018 Aug 3;140:107-120.

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PQR-530 (PQR530, PQR 530)

Biological Activity

Physicochemical Properties

References

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