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LAS195319

Chemical Structure : LAS195319

CAS No.: 1605328-04-8

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LAS195319 (LAS-195319;LAS 195319)

Catalog No.: PC-35745Not For Human Use, Lab Use Only.

LAS195319 (LAS-195319) is a potent, selective, inhaled PI3Kδ inhibitor with IC50 of 0.5 nM, weakly inhibits PI3Kβ and γ (>20-fold), no activity against PI3Kα.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    LAS195319 (LAS-195319) is a potent, selective, inhaled PI3Kδ inhibitor with IC50 of 0.5 nM, weakly inhibits PI3Kβ and γ (>20-fold), no activity against PI3Kα.
    LAS195319 inhibits M-CSF induced pAkt (Thr308) in THP-1 cells with IC50 of 2.7 nM.
    LAS195319 inhibits inflammatory cell infiltration induced by OVA challenge in a Brown Norway rat model.

    Physicochemical Properties

    M.Wt 594.654
    Formula C29H26N10O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-[4-(4-{[(1S)-1-(5-Methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-1H-indol-6-yl]sulfamide

    References

    1. Erra M, et al. J Med Chem. 2018 Oct 29. doi: 10.1021/acs.jmedchem.8b00873.

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