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Chemical Structure : LAS195319
Catalog No.: PC-35745Not For Human Use, Lab Use Only.
LAS195319 (LAS-195319) is a potent, selective, inhaled PI3Kδ inhibitor with IC50 of 0.5 nM, weakly inhibits PI3Kβ and γ (>20-fold), no activity against PI3Kα.
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LAS195319 (LAS-195319) is a potent, selective, inhaled PI3Kδ inhibitor with IC50 of 0.5 nM, weakly inhibits PI3Kβ and γ (>20-fold), no activity against PI3Kα.
LAS195319 inhibits M-CSF induced pAkt (Thr308) in THP-1 cells with IC50 of 2.7 nM.
LAS195319 inhibits inflammatory cell infiltration induced by OVA challenge in a Brown Norway rat model.
| M.Wt | 594.654 | |
| Formula | C29H26N10O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Erra M, et al. J Med Chem. 2018 Oct 29. doi: 10.1021/acs.jmedchem.8b00873.
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