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Chemical Structure : A66
CAS No.: 1166227-08-2
Catalog No.: PC-43441Not For Human Use, Lab Use Only.
A66 (p110α inhibitor A66) is a potent, highly specific p110α inhibitor with IC50 of 32, 30 and 43 nM for wt p110α, p110α E545K and p110α H1047R, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 25 mg | $168 | In stock | |
| 100 mg | $358 | In stock | |
| 500 mg | Get quote |
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A66 (p110α inhibitor A66) is a potent, highly specific p110α inhibitor with IC50 of 32, 30 and 43 nM for wt p110α, p110α E545K and p110α H1047R, respectively.
A66 displays little to no activity against p110β/γ/δ (IC50>3,000 nM), as well as class-III PI3Ks, mTOR, DNA-PK, and PI4Kα/β.
A66 induces reduction in focus formation CEF by the highly transforming iSH2 mutants KS459delN, DKRMNS560del, and K379E, blocks PI3K signalling and tumour growth in certain cell types.
| M.Wt | 393.53 | |
| Formula | C17H23N5O2S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1,2-Pyrrolidinedicarboxamide, N1-[2-(1,1-dimethylethyl)-4'-methyl[4,5'-bithiazol]-2'-yl]-, (2S)- |
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1. Jamieson S, et al. Biochem J. 2011 Aug 15;438(1):53-62.
2. Sun M, et al. Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15547-52.
3. Weigelt B, et al. Clin Cancer Res. 2013 Jul 1;19(13):3533-44.
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