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Chemical Structure : LX-2343
CAS No.: 333745-53-2
Catalog No.: PC-63276Not For Human Use, Lab Use Only.
LX-2343 (LX2343) is an non-ATP competitive PI3K inhibitor that negatively regulates AKT/mTOR signaling, thus promoting autophagy and increasing Aβ clearance, also inhibits BACE1 enzymatic activity with IC50 of 11.43 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $368 | In stock | |
| 100 mg | Get quote |
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LX-2343 (LX2343) is an non-ATP competitive PI3K inhibitor that negatively regulates AKT/mTOR signaling, thus promoting autophagy and increasing Aβ clearance, also inhibits BACE1 enzymatic activity with IC50 of 11.43 uM.
LX-2343 reduced Aβ production involving JNK/APPThr668 pathway inhibition.
LX-2343 LX2343 (5-20 uM) dose-dependently decreases Aβ accumulation in HEK293-APPsw and CHO-APP cells, and promotes Aβ clearance in SH-SY5Y cells and primary astrocytes.
LX-2343 significantly ameliorates cognitive deficits and markedly ameliorates the Aβ pathology in brains in APP/PS1 transgenic mice.
| M.Wt | 474.912 | |
| Formula | C22H19ClN2O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-(1,3-benzodioxol-5-yl)-2-[5-chloro-2-methoxy(phenylsulfonyl)anilino]acetamide |
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1. Guo XD, et al. Acta Pharmacol Sin. 2016 Sep;37(10):1281-1297.
2. Guo XD, et al. Acta Pharmacol Sin. 2017 Aug;38(8):1104-1119.
3. Sun G, et al. Eur J Med Chem. 2018 Feb 10;145:622-633.
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