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Chemical Structure : Idelalisib
CAS No.: 870281-82-6
Catalog No.: PC-43336Not For Human Use, Lab Use Only.
Idelalisib (CAL-101, GS-1101) is a potent, selective inhibitor of PI3K p110δ with IC50 of 2.5 nM, 40- to 300-fold selectivity over other class I PI3Ks (p110α/βγ, IC50=820/565/89nM), and 400- to 4000-fold over C2β, hVPS34, DNA-PK, and mTOR.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $128 | In stock | |
| 100 mg | $188 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Idelalisib (CAL-101, GS-1101) is a potent, selective inhibitor of PI3K p110δ with IC50 of 2.5 nM, 40- to 300-fold selectivity over other class I PI3Ks (p110α/βγ, IC50=820/565/89nM), and 400- to 4000-fold over C2β, hVPS34, DNA-PK, and mTOR.
Idelalisib (CAL-101, GS-1101) blocks FcϵRI p110δ-mediated CD63 expression in basophils with an EC50 of 8 nM.
Idelalisib (CAL-101, GS-1101) blocks constitutive PI3K signaling, resulting in decreased phosphorylation of Akt and other downstream effectors, an increase in PARP and caspase cleavage and an induction of apoptosis in multiple B-cell malignancies.
| M.Wt | 415.423 | |
| Formula | C22H18FN7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 59.7 mg/mL |
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| Chemical Name/SMILES |
4(3H)-Quinazolinone, 5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]- |
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1. Hoellenriegel J, et al. Blood. 2011 Sep 29;118(13):3603-12.
2. Herman SE, et al. Blood. 2010 Sep 23;116(12):2078-88.
3. Lannutti BJ, et al. Blood. 2011 Jan 13;117(2):591-4.
4. Bodo J, et al. Br J Haematol. 2013 Oct;163(1):72-80.
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