Catalog No.: PC-49021Not For Human Use, Lab Use Only.
PF-06843195 is a potent, selective PI3Kα inhibitor with Ki value of <0.018 nM, IC50 of 18 nM (RAT1 PI3Kα), with cellular isoform selectivity of 20-fold over PI3Kβ and 9-fold over PI3Kδ.
PF-06843195 is a potent, selective PI3Kα inhibitor with Ki value of <0.018 nM, IC50 of 18 nM (RAT1 PI3Kα), with cellular isoform selectivity of 20-fold over PI3Kβ and 9-fold over PI3Kδ.
PF-06843195 also demonstrated high selectivity over mTOR.
PF-06843195 is a potent inhibitor of both PI3Kα (Ki< 0.018 nM) and PI3Kδ (Ki< 0.28 nM), but found to be 9-fold selective for PI3Kα over PI3Kδ in cell assays.
PF-06843195 is selective over two other members of the class I catalytic PI3K kinase group, PI3Kβ and PI3Kγ, >100- and >10 000-fold, respectively, in biochemical assays and 20-fold selective over PI3Kβ in cell assays.
