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Amdizalisib

Chemical Structure : Amdizalisib

CAS No.: 1894229-05-0

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Amdizalisib (HMPL-689, HMPL689)

Catalog No.: PC-38383Not For Human Use, Lab Use Only.

Amdizalisib (HMPL-689) is a highly selective and potent oral inhibitor of phosphoinositide 3-kinase-delta (PI3Kδ) with potential antineoplastic activity.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Amdizalisib (HMPL-689) is a highly selective and potent oral inhibitor of phosphoinositide 3-kinase-delta (PI3Kδ) with potential antineoplastic activity.
    Amdizalisib (HMPL-689) is under clinical investigation for the treatment of relapsed or refractory follicular lymphoma (FL), a subtype of non-Hodgkin's lymphoma (NHL).

    Physicochemical Properties

    M.Wt 390.835
    Formula C19H15ClN8
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]pyridazin-7-yl)ethyl)amino)pyrimidine-5-carbonitrile

    References

    1. Tunde Lawrence, et al. Cancer Res (2020) 80 (16_Supplement): 5234.

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