Catalog No.: PC-24602Not For Human Use, Lab Use Only.
Deguelin is a naturally occurring rotenoid, acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt, IKK-NF-κB, and MAPK-mTOR-survivin-mediated apoptosis, also is a potential inhibitor of FBXO22.
Deguelin is a naturally occurring rotenoid, acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt, IKK-NF-κB, and MAPK-mTOR-survivin-mediated apoptosis, also is a potential inhibitor of FBXO22. Deguelin enhanced radiosensitivity in an FBXO22/Rad51-dependent manner and was safely tolerated in vivo. Deguelin binding to Hsp90 leads to a decreased expression of numerous oncogenic proteins, including MEK1/2, Akt, HIF1α, COX-2, and NF-κB. Deguelin exerts antitumor and chemopreventive effects by targeting multiple oncogenic signaling pathways.
