F0608-0019

Chemical Structure : F0608-0019

Catalog No.: PC-24150Not For Human Use, Lab Use Only.

F0608-0019 is a highly potent and selective PI3Kα inhibitor with IC50 of 0.47 uM.

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Biological Activity

F0608-0019 is a highly potent and selective PI3Kα inhibitor with IC50 of 0.47 uM.
F0608-0019 has minimal impact on PI3Kβ with only a 5% inhibition and a moderate reduction in PI3Kγ activity by 26.9% at 10 uM.
F0608-0019 displays remarkable efficacy in suppressing HCT116 colorectal cancer cell proliferation, with an IC50 of 12.14 uM.

Physicochemical Properties

M.Wt	427.42
Formula	C24H17N3O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-benzoyl-N-(5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1,3,4-oxadiazol-2-yl)benzamide

References

1. Albassam H, et al. J Enzyme Inhib Med Chem. 2025 Dec;40(1):2468852.

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F0608-0019

Biological Activity

Physicochemical Properties

References

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