Chemical Structure : DW09849
CAS No.:
1621363-81-2
DW09849
Catalog No.: PC-25286Not For Human Use, Lab Use Only.
DW09849 is a highly potent, selective PI3Kα inhibitor, inhibits proliferation of rhabdomyosarcoma RH30 cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
DW09849 is a highly potent, selective PI3Kα inhibitor, inhibits proliferation of rhabdomyosarcoma RH30 cells.
DW09849 significantly and persistently blocks PI3K/protein kinase B signaling in RH30 cells, which consequently arrested RH30 cells in the G1 phase.
DW09849 selectively suppresses the proliferation and clonogenesis of transformed RK3E/HR cells harboring oncogenic mutation of p110α H1047R, as well as a panel of human breast cancer cells containing mutated PI3Kα.
DW09849 demonstrates preference against H1047R mutated PI3Kα in molecular docking stimulation.
DW09849 selectively targeting PI3Kα with less off-target effects than PIK-75.
Physicochemical Properties
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M.Wt
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430.26
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Formula
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C18H16BrN5O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(E)-N'-((6-bromoimidazo[1,2-a]pyridin-3-yl)methylene)-N-ethyl-2-methyl-5-nitrobenzohydrazide
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References
1. Liu JL, et al. J Pharmacol Exp Ther. 2014 Mar;348(3):432-41.
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