D223 | GLUT4 activator | Probechem Biochemicals

Chemical Structure : D223

D223 (DS02312223)

Catalog No.: PC-25225Not For Human Use, Lab Use Only.

D927 (DS11252927) is a small molecule glue and GLUT4 activator that facilitate RAS binding to PI3Kα, promotes glucose uptake in the absence of insulin, binds directly to p110α with dissociation constant (KD) of 0.76 uM.

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Biological Activity

Physicochemical Properties

M.Wt	581.66
Formula	C29H32FN5O5S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	tert-butyl (2-(2-(2-(4-((4-(2-amino-2-oxoethyl)-2-fluorophenyl)amino)thieno[2,3-d]pyridazin-7-yl)phenoxy)ethoxy)ethyl)carbamate

References

1. Terayama K, et al. Science. 2025 Jul 24;389(6758):402-408.

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D223 (DS02312223)

Biological Activity

Physicochemical Properties

References

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