LY294002 is a classic, broad-spectrum PI3K inhibitor with IC50 of 0.5/0.57/0.97 uM for PI3Kα/δ/β, respectively.
LY294002 completely and specifically abolishes PI3K activity (IC50=1.4 uM), but does not inhibit PI4K or other lipid kinases.
LY294002 demonstrates growth-inhibitory and apoptosis-inducing effect in colon cancer cell lines, with decreased phosphorylated Akt Ser(473).
LY294002 suppresses tumor growth in mouse xenografts.
LY294002 also is a potent inhibitor of CK2 with IC50 of 98 nM.
