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Chemical Structure : LY294002
CAS No.: 154447-36-6
Catalog No.: PC-42310Not For Human Use, Lab Use Only.
LY294002 is a classic, broad-spectrum PI3K inhibitor with IC50 of 0.5/0.57/0.97 uM for PI3Kα/δ/β, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $128 | In stock | |
| 100 mg | $188 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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LY294002 is a classic, broad-spectrum PI3K inhibitor with IC50 of 0.5/0.57/0.97 uM for PI3Kα/δ/β, respectively.
LY294002 completely and specifically abolishes PI3K activity (IC50=1.4 uM), but does not inhibit PI4K or other lipid kinases.
LY294002 demonstrates growth-inhibitory and apoptosis-inducing effect in colon cancer cell lines, with decreased phosphorylated Akt Ser(473).
LY294002 suppresses tumor growth in mouse xenografts.
LY294002 also is a potent inhibitor of CK2 with IC50 of 98 nM.
| M.Wt | 307.3432 | |
| Formula | C19H17NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 14.9 mg/mL |
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| Chemical Name/SMILES |
4H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl- |
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1. Vlahos CJ, et al. J Biol Chem. 1994 Feb 18;269(7):5241-8.
2. Cheatham B, et al. Mol Cell Biol. 1994 Jul;14(7):4902-11.
3. Semba S, et al. Clin Cancer Res. 2002 Jun;8(6):1957-63.
4. Gharbi SI, et al. Biochem J. 2007 May 15;404(1):15-21.
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