Chemical Structure : SBS-873
CAS No.:
SBS-873
(SBS873)
Catalog No.: PC-28409Not For Human Use, Lab Use Only.
SBS-873 is a first-in-class p110α/GDH1 (Glutamate dehydrogenase 1) dual inhibitor, downregulates the p110α subunit, and suppresses PI3K/Akt/mTOR pathway, triggers ferroptotic cell death through glutathione depletion, GPX4 impairment, and lipid peroxidation.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SBS-873 is a first-in-class p110α/GDH1 (Glutamate dehydrogenase 1) dual inhibitor, downregulates the p110α subunit, and suppresses PI3K/Akt/mTOR pathway, triggers ferroptotic cell death through glutathione depletion, GPX4 impairment, and lipid peroxidation.
SBS-873 inhibits invasion and epithelial-mesenchymal transition in TNBC.
SBS-873 exhibits antiproliferative activity across TNBC (BT-549 and Hs 578T), luminal (T47D and MCF-7), and HER2-positive (BT-474) breast cancer cell lines.
SBS-873 induces GDH1-dependent ferroptosis in TNBC cells.
SBS-873 impairs mitochondrial respiration through GDH1-dependent ferroptosis.
SBS-873 inhibits the tumor growth in BT-549 xenograft-bearing mice.
SBS-873 is capable of simultaneously impairing proliferative signaling, metabolic adaptation, metastatic potential, and redox homeostasis.
Physicochemical Properties
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M.Wt
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466.60
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Formula
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C24H30N6O2S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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