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Chemical Structure : 14-3-3 inhibitor BV02
CAS No.: 302602-92-2
Catalog No.: PC-61231Not For Human Use, Lab Use Only.
14-3-3 inhibitor BV02 is a novel nonpeptidic inhibitor of 14-3-3 protein-protein interaction that promotes the apoptotic death of cells expressing either wt Bcr-Abl construct or T315I mutation.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
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| 100 mg | Get quote |
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14-3-3 inhibitor BV02 is a novel nonpeptidic inhibitor of 14-3-3 protein-protein interaction that promotes the apoptotic death of cells expressing either wt Bcr-Abl construct or T315I mutation.
BV02 induces significant dose-dependent reduction of reproductive integrity of Ba/F3 cells expressing the wt and T315I-mutated Bcr-Abl with LD50 of 1.04 and 1.47 uM, respectively.
BV02 promoted c-Abl release from 14-3-3σ, abolishes c-Abl expression in the cytoplasm, but has no influence on 14-3-3σ levels.
BV02 induces apoptotic cell death in chronic myeloid leukemia sensitive or resistant to imatinib.
| M.Wt | 395.371 | |
| Formula | C20H17N3O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)carbamoyl)terephthalic acid |
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1. Mancini M, et al. J Pharmacol Exp Ther. 2011 Mar;336(3):596-604.
2. Mohammad DK, et al. Mol Cell Biol. 2013 Aug;33(16):3214-26.
3. Gómez-Suárez M, et al. Cell Death Differ. 2016 Jun;23(6):1060-72.
4. Valensin D, et al. Bioorg Med Chem Lett. 2016 Feb 1;26(3):894-898.
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