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Chemical Structure : RB-011
Catalog No.: PC-61238Not For Human Use, Lab Use Only.
RB-011 is a small molecule that disrupt 14-3-3 dimers at low micromolar concentrations and induce rapid down-regulation of Raf-MAPK and PI3K-Akt signaling in Jurkat cells.
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RB-011 is a small molecule that disrupt 14-3-3 dimers at low micromolar concentrations and induce rapid down-regulation of Raf-MAPK and PI3K-Akt signaling in Jurkat cells.
RB-011 has ED50 of 3 uM for apoptosis induction in Jurkat cells, inhibits A549 lung cancer cell growth in vitro and in vivo.
RB-011 exhibits a rounded morphology similar to that of 14-3-3ζ KO dermal fibroblasts, increasing signal flux through the ROCK pathway, impairing the ECM remodeling, and accelerating wound healing.
| M.Wt | 302.525 | |
| Formula | C21H36N+ | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Woodcock JM, et al. Oncotarget. 2015 Jun 10;6(16):14522-36.
2. Kular J, et al. Dev Cell. 2015 Dec 21;35(6):759-74.
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