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RB-011

Chemical Structure : RB-011

CAS No.: 1425049-26-8

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RB-011 (RB011, RB11)

Catalog No.: PC-61238Not For Human Use, Lab Use Only.

RB-011 is a small molecule that disrupt 14-3-3 dimers at low micromolar concentrations and induce rapid down-regulation of Raf-MAPK and PI3K-Akt signaling in Jurkat cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    RB-011 is a small molecule that disrupt 14-3-3 dimers at low micromolar concentrations and induce rapid down-regulation of Raf-MAPK and PI3K-Akt signaling in Jurkat cells.
    RB-011 has ED50 of 3 uM for apoptosis induction in Jurkat cells, inhibits A549 lung cancer cell growth in vitro and in vivo.
    RB-011 exhibits a rounded morphology similar to that of 14-3-3ζ KO dermal fibroblasts, increasing signal flux through the ROCK pathway, impairing the ECM remodeling, and accelerating wound healing.

    Physicochemical Properties

    M.Wt 302.525
    Formula C21H36N+
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-methyl-1-(4-octylphenethyl)pyrrolidin-1-ium

    References

    1. Woodcock JM, et al. Oncotarget. 2015 Jun 10;6(16):14522-36.

    2. Kular J, et al. Dev Cell. 2015 Dec 21;35(6):759-74.

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