14-3-3-ERα stabilizer 41

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Chemical Structure : 14-3-3-ERα stabilizer 41

Catalog No.: PC-25264Not For Human Use, Lab Use Only.

14-3-3/ERα stabilizer 41 is a potent, selective and covalent small-molecule stabilizer of the 14-3-3σ/ERα complex, forms a covalent bond with C38 of 14-3-3σ, shows remarkable selectivity for 14-3-3σ/ERα (KD=10.1 nM).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	436.92
Formula	C24H22ClFN4O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-chloro-N-(4-(3-((2,6-dimethylphenyl)amino)-6-methylimidazo[1,2-a]pyridin-2-yl)-3-fluorophenyl)acetamide

References

1. Konstantinidou M, et al. Nat Commun. 2025 Jul 14;16(1):6467.

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