14-3-3-ERα stabilizer 127 | CAS 3057296-45-1

Chemical Structure : 14-3-3-ERα stabilizer 127

14-3-3-ERα stabilizer 127 (14-3-3/ERα stabilizer)

Catalog No.: PC-25262Not For Human Use, Lab Use Only.

14-3-3/ERα stabilizer 127 is a potent, covalent, small-molecule stabilizer of the 14-3-3σ/ERα complex with EC50 of 2.0 uM, forms a covalent bond with C38 of 14-3-3σ.

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Biological Activity

14-3-3/ERα stabilizer 127 is a potent, covalent, small-molecule stabilizer of the 14-3-3σ/ERα complex with EC50 of 2.0 uM, forms a covalent bond with C38 of 14-3-3σ.

Physicochemical Properties

M.Wt	428.35
Formula	C20H27Cl2N3O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-chloro-N-((1-(4-((4-chlorophenyl)amino)tetrahydro-2H-pyran-4-carbonyl)piperidin-4-yl)methyl)acetamide

References

1. Konstantinidou M, et al. J Am Chem Soc. 2023 Sep 20;145(37):20328-20343.

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14-3-3-ERα stabilizer 127 (14-3-3/ERα stabilizer)

Biological Activity

Physicochemical Properties

References

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